Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers
نویسندگان
چکیده
منابع مشابه
Comparative Analysis of Proteome and Transcriptome Variation in Mouse
The relationships between the levels of transcripts and the levels of the proteins they encode have not been examined comprehensively in mammals, although previous work in plants and yeast suggest a surprisingly modest correlation. We have examined this issue using a genetic approach in which natural variations were used to perturb both transcript levels and protein levels among inbred strains ...
متن کاملTranscriptome and Proteome Analysis using Signature Tags
With the full sequence of the human genome now available, an exciting era in biomedical research has started. The sequence provides information about all our genes and greatly increases the scope to compare genetic activities in different cells, to analyze genetic variation between individuals and between different species and, most importantly, to investigate systematically the whole genome in...
متن کاملMouse proteome analysis.
A general overview of the protein sequence set for the mouse transcriptome produced during the FANTOM2 sequencing project is presented here. We applied different algorithms to characterize protein sequences derived from a nonredundant representative protein set (RPS) and a variant protein set (VPS) of the mouse transcriptome. The functional characterization and assignment of Gene Ontology terms...
متن کاملProteome analysis of lens epithelia, fibers, and the HLE B-3 cell line.
PURPOSE The purpose of this study is to compare the protein composition of the B-3 line of transformed human lens epithelial (HLE) cells to that of freshly dissected HLE cells. This provides baseline data on lens cell proteins from fresh lens cells and from the B-3 cell line, which is often used as a model system for the lens. METHODS Human lens epithelial cells adherent to the lens capsule w...
متن کاملIdentification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues.
A major advantage of the mouse model lies in the increasing information on its genome, transcriptome, and proteome, as well as in the availability of a fast growing number of targeted and induced mutant alleles. However, data from comparative transcriptome and proteome analyses in this model organism are very limited. We use DNA chip-based RNA expression profiling and 2D gel electrophoresis, co...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2019
ISSN: 0014-4835
DOI: 10.1016/j.exer.2018.10.011